seqfeat.asn
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- --
- -- ===========================================================================
- -- PRODUCTION $Log: seqfeat.asn,v $
- -- PRODUCTION Revision 1000.0 2003/10/29 21:33:45 gouriano
- -- PRODUCTION PRODUCTION: IMPORTED [ORIGINAL] Dev-tree R6.9
- -- PRODUCTION
- -- ===========================================================================
- --
- --$Revision: 1000.0 $
- --**********************************************************************
- --
- -- NCBI Sequence Feature elements
- -- by James Ostell, 1990
- -- Version 3.0 - June 1994
- --
- --**********************************************************************
- NCBI-Seqfeat DEFINITIONS ::=
- BEGIN
- EXPORTS Seq-feat, Feat-id, Genetic-code;
- IMPORTS Gene-ref FROM NCBI-Gene
- Prot-ref FROM NCBI-Protein
- Org-ref FROM NCBI-Organism
- BioSource FROM NCBI-BioSource
- RNA-ref FROM NCBI-RNA
- Seq-loc, Giimport-id FROM NCBI-Seqloc
- Pubdesc, Numbering, Heterogen FROM NCBI-Sequence
- Rsite-ref FROM NCBI-Rsite
- Txinit FROM NCBI-TxInit
- Pub-set FROM NCBI-Pub
- Object-id, Dbtag, User-object FROM NCBI-General;
- --*** Feature identifiers ********************************
- --*
- Feat-id ::= CHOICE {
- gibb INTEGER , -- geninfo backbone
- giim Giimport-id , -- geninfo import
- local Object-id , -- for local software use
- general Dbtag } -- for use by various databases
- --*** Seq-feat *******************************************
- --* sequence feature generalization
- Seq-feat ::= SEQUENCE {
- id Feat-id OPTIONAL ,
- data SeqFeatData , -- the specific data
- partial BOOLEAN OPTIONAL , -- incomplete in some way?
- except BOOLEAN OPTIONAL , -- something funny about this?
- comment VisibleString OPTIONAL ,
- product Seq-loc OPTIONAL , -- product of process
- location Seq-loc , -- feature made from
- qual SEQUENCE OF Gb-qual OPTIONAL , -- qualifiers
- title VisibleString OPTIONAL , -- for user defined label
- ext User-object OPTIONAL , -- user defined structure extension
- cit Pub-set OPTIONAL , -- citations for this feature
- exp-ev ENUMERATED { -- evidence for existence of feature
- experimental (1) , -- any reasonable experimental check
- not-experimental (2) } OPTIONAL , -- similarity, pattern, etc
- xref SET OF SeqFeatXref OPTIONAL , -- cite other relevant features
- dbxref SET OF Dbtag OPTIONAL , -- support for xref to other databases
- pseudo BOOLEAN OPTIONAL , -- annotated on pseudogene?
- except-text VisibleString OPTIONAL } -- explain if except=TRUE
- SeqFeatData ::= CHOICE {
- gene Gene-ref ,
- org Org-ref ,
- cdregion Cdregion ,
- prot Prot-ref ,
- rna RNA-ref ,
- pub Pubdesc , -- publication applies to this seq
- seq Seq-loc , -- to annotate origin from another seq
- imp Imp-feat ,
- region VisibleString, -- named region (globin locus)
- comment NULL , -- just a comment
- bond ENUMERATED {
- disulfide (1) ,
- thiolester (2) ,
- xlink (3) ,
- thioether (4) ,
- other (255) } ,
- site ENUMERATED {
- active (1) ,
- binding (2) ,
- cleavage (3) ,
- inhibit (4) ,
- modified (5),
- glycosylation (6) ,
- myristoylation (7) ,
- mutagenized (8) ,
- metal-binding (9) ,
- phosphorylation (10) ,
- acetylation (11) ,
- amidation (12) ,
- methylation (13) ,
- hydroxylation (14) ,
- sulfatation (15) ,
- oxidative-deamination (16) ,
- pyrrolidone-carboxylic-acid (17) ,
- gamma-carboxyglutamic-acid (18) ,
- blocked (19) ,
- lipid-binding (20) ,
- np-binding (21) ,
- dna-binding (22) ,
- signal-peptide (23) ,
- transit-peptide (24) ,
- transmembrane-region (25) ,
- other (255) } ,
- rsite Rsite-ref , -- restriction site (for maps really)
- user User-object , -- user defined structure
- txinit Txinit , -- transcription initiation
- num Numbering , -- a numbering system
- psec-str ENUMERATED { -- protein secondary structure
- helix (1) , -- any helix
- sheet (2) , -- beta sheet
- turn (3) } , -- beta or gamma turn
- non-std-residue VisibleString , -- non-standard residue here in seq
- het Heterogen , -- cofactor, prosthetic grp, etc, bound to seq
- biosrc BioSource }
- SeqFeatXref ::= SEQUENCE { -- both optional because can have one or both
- id Feat-id OPTIONAL , -- the feature copied
- data SeqFeatData OPTIONAL } -- the specific data
-
- --*** CdRegion ***********************************************
- --*
- --* Instructions to translate from a nucleic acid to a peptide
- --* conflict means it's supposed to translate but doesn't
- --*
- Cdregion ::= SEQUENCE {
- orf BOOLEAN OPTIONAL , -- just an ORF ?
- frame ENUMERATED {
- not-set (0) , -- not set, code uses one
- one (1) ,
- two (2) ,
- three (3) } DEFAULT not-set , -- reading frame
- conflict BOOLEAN OPTIONAL , -- conflict
- gaps INTEGER OPTIONAL , -- number of gaps on conflict/except
- mismatch INTEGER OPTIONAL , -- number of mismatches on above
- code Genetic-code OPTIONAL , -- genetic code used
- code-break SEQUENCE OF Code-break OPTIONAL , -- individual exceptions
- stops INTEGER OPTIONAL } -- number of stop codons on above
- -- each code is 64 cells long, in the order where
- -- T=0,C=1,A=2,G=3, TTT=0, TTC=1, TCA=4, etc
- -- NOTE: this order does NOT correspond to a Seq-data
- -- encoding. It is "natural" to codon usage instead.
- -- the value in each cell is the AA coded for
- -- start= AA coded only if first in peptide
- -- in start array, if codon is not a legitimate start
- -- codon, that cell will have the "gap" symbol for
- -- that alphabet. Otherwise it will have the AA
- -- encoded when that codon is used at the start.
- Genetic-code ::= SET OF CHOICE {
- name VisibleString , -- name of a code
- id INTEGER , -- id in dbase
- ncbieaa VisibleString , -- indexed to IUPAC extended
- ncbi8aa OCTET STRING , -- indexed to NCBI8aa
- ncbistdaa OCTET STRING , -- indexed to NCBIstdaa
- sncbieaa VisibleString , -- start, indexed to IUPAC extended
- sncbi8aa OCTET STRING , -- start, indexed to NCBI8aa
- sncbistdaa OCTET STRING } -- start, indexed to NCBIstdaa
- Code-break ::= SEQUENCE { -- specific codon exceptions
- loc Seq-loc , -- location of exception
- aa CHOICE { -- the amino acid
- ncbieaa INTEGER , -- ASCII value of NCBIeaa code
- ncbi8aa INTEGER , -- NCBI8aa code
- ncbistdaa INTEGER } } -- NCBIstdaa code
- Genetic-code-table ::= SET OF Genetic-code -- table of genetic codes
- --*** Import ***********************************************
- --*
- --* Features imported from other databases
- --*
- Imp-feat ::= SEQUENCE {
- key VisibleString ,
- loc VisibleString OPTIONAL , -- original location string
- descr VisibleString OPTIONAL } -- text description
- Gb-qual ::= SEQUENCE {
- qual VisibleString ,
- val VisibleString }
- END
- --**********************************************************************
- --
- -- NCBI Restriction Sites
- -- by James Ostell, 1990
- -- version 0.8
- --
- --**********************************************************************
- NCBI-Rsite DEFINITIONS ::=
- BEGIN
- EXPORTS Rsite-ref;
- IMPORTS Dbtag FROM NCBI-General;
- Rsite-ref ::= CHOICE {
- str VisibleString , -- may be unparsable
- db Dbtag } -- pointer to a restriction site database
- END
- --**********************************************************************
- --
- -- NCBI RNAs
- -- by James Ostell, 1990
- -- version 0.8
- --
- --**********************************************************************
- NCBI-RNA DEFINITIONS ::=
- BEGIN
- EXPORTS RNA-ref, Trna-ext;
- IMPORTS Seq-loc FROM NCBI-Seqloc;
- --*** rnas ***********************************************
- --*
- --* various rnas
- --*
- -- minimal RNA sequence
- RNA-ref ::= SEQUENCE {
- type ENUMERATED { -- type of RNA feature
- unknown (0) ,
- premsg (1) ,
- mRNA (2) ,
- tRNA (3) ,
- rRNA (4) ,
- snRNA (5) ,
- scRNA (6) ,
- snoRNA (7) ,
- other (255) } ,
- pseudo BOOLEAN OPTIONAL ,
- ext CHOICE {
- name VisibleString , -- for naming "other" type
- tRNA Trna-ext } OPTIONAL } -- for tRNAs
- Trna-ext ::= SEQUENCE { -- tRNA feature extensions
- aa CHOICE { -- aa this carries
- iupacaa INTEGER ,
- ncbieaa INTEGER ,
- ncbi8aa INTEGER ,
- ncbistdaa INTEGER } OPTIONAL ,
- codon SET OF INTEGER OPTIONAL , -- codon(s) as in Genetic-code
- anticodon Seq-loc OPTIONAL } -- location of anticodon
- END
- --**********************************************************************
- --
- -- NCBI Genes
- -- by James Ostell, 1990
- -- version 0.8
- --
- --**********************************************************************
- NCBI-Gene DEFINITIONS ::=
- BEGIN
- EXPORTS Gene-ref;
- IMPORTS Dbtag FROM NCBI-General;
- --*** Gene ***********************************************
- --*
- --* reference to a gene
- --*
- Gene-ref ::= SEQUENCE {
- locus VisibleString OPTIONAL , -- Official gene symbol
- allele VisibleString OPTIONAL , -- Official allele designation
- desc VisibleString OPTIONAL , -- descriptive name
- maploc VisibleString OPTIONAL , -- descriptive map location
- pseudo BOOLEAN DEFAULT FALSE , -- pseudogene
- db SET OF Dbtag OPTIONAL , -- ids in other dbases
- syn SET OF VisibleString OPTIONAL , -- synonyms for locus
- locus-tag VisibleString OPTIONAL } -- systematic gene name (e.g., MI0001, ORF0069)
- END
- --**********************************************************************
- --
- -- NCBI Organism
- -- by James Ostell, 1994
- -- version 3.0
- --
- --**********************************************************************
- NCBI-Organism DEFINITIONS ::=
- BEGIN
- EXPORTS Org-ref;
- IMPORTS Dbtag FROM NCBI-General;
- --*** Org-ref ***********************************************
- --*
- --* Reference to an organism
- --* defines only the organism.. lower levels of detail for biological
- --* molecules are provided by the Source object
- --*
- Org-ref ::= SEQUENCE {
- taxname VisibleString OPTIONAL , -- preferred formal name
- common VisibleString OPTIONAL , -- common name
- mod SET OF VisibleString OPTIONAL , -- unstructured modifiers
- db SET OF Dbtag OPTIONAL , -- ids in taxonomic or culture dbases
- syn SET OF VisibleString OPTIONAL , -- synonyms for taxname or common
- orgname OrgName OPTIONAL }
-
- OrgName ::= SEQUENCE {
- name CHOICE {
- binomial BinomialOrgName , -- genus/species type name
- virus VisibleString , -- virus names are different
- hybrid MultiOrgName , -- hybrid between organisms
- namedhybrid BinomialOrgName , -- some hybrids have genus x species name
- partial PartialOrgName } OPTIONAL , -- when genus not known
- attrib VisibleString OPTIONAL , -- attribution of name
- mod SEQUENCE OF OrgMod OPTIONAL ,
- lineage VisibleString OPTIONAL , -- lineage with semicolon separators
- gcode INTEGER OPTIONAL , -- genetic code (see CdRegion)
- mgcode INTEGER OPTIONAL , -- mitochondrial genetic code
- div VisibleString OPTIONAL } -- GenBank division code
-
- OrgMod ::= SEQUENCE {
- subtype INTEGER {
- strain (2) ,
- substrain (3) ,
- type (4) ,
- subtype (5) ,
- variety (6) ,
- serotype (7) ,
- serogroup (8) ,
- serovar (9) ,
- cultivar (10) ,
- pathovar (11) ,
- chemovar (12) ,
- biovar (13) ,
- biotype (14) ,
- group (15) ,
- subgroup (16) ,
- isolate (17) ,
- common (18) ,
- acronym (19) ,
- dosage (20) , -- chromosome dosage of hybrid
- nat-host (21) , -- natural host of this specimen
- sub-species (22) ,
- specimen-voucher (23) ,
- authority (24) ,
- forma (25) ,
- forma-specialis (26) ,
- ecotype (27) ,
- synonym (28) ,
- anamorph (29) ,
- teleomorph (30) ,
- breed (31) ,
- gb-acronym (32) , -- used by taxonomy database
- gb-anamorph (33) , -- used by taxonomy database
- gb-synonym (34) , -- used by taxonomy database
- old-lineage (253) ,
- old-name (254) ,
- other (255) } , -- ASN5: old-name (254) will be added to next spec
- subname VisibleString ,
- attrib VisibleString OPTIONAL } -- attribution/source of name
- BinomialOrgName ::= SEQUENCE {
- genus VisibleString , -- required
- species VisibleString OPTIONAL , -- species required if subspecies used
- subspecies VisibleString OPTIONAL }
- MultiOrgName ::= SEQUENCE OF OrgName -- the first will be used to assign division
- PartialOrgName ::= SEQUENCE OF TaxElement -- when we don't know the genus
- TaxElement ::= SEQUENCE {
- fixed-level INTEGER {
- other (0) , -- level must be set in string
- family (1) ,
- order (2) ,
- class (3) } ,
- level VisibleString OPTIONAL ,
- name VisibleString }
- END
- --**********************************************************************
- --
- -- NCBI BioSource
- -- by James Ostell, 1994
- -- version 3.0
- --
- --**********************************************************************
- NCBI-BioSource DEFINITIONS ::=
- BEGIN
- EXPORTS BioSource;
- IMPORTS Org-ref FROM NCBI-Organism;
- --********************************************************************
- --
- -- BioSource gives the source of the biological material
- -- for sequences
- --
- --********************************************************************
- BioSource ::= SEQUENCE {
- genome INTEGER { -- biological context
- unknown (0) ,
- genomic (1) ,
- chloroplast (2) ,
- chromoplast (3) ,
- kinetoplast (4) ,
- mitochondrion (5) ,
- plastid (6) ,
- macronuclear (7) ,
- extrachrom (8) ,
- plasmid (9) ,
- transposon (10) ,
- insertion-seq (11) ,
- cyanelle (12) ,
- proviral (13) ,
- virion (14) ,
- nucleomorph (15) ,
- apicoplast (16) ,
- leucoplast (17) ,
- proplastid (18) ,
- endogenous-virus (19)
- } DEFAULT unknown ,
- -- 4 more genome values coming
- -- nucleomorph (15)
- -- apicoplast (16)
- -- leucoplast (17)
- -- proplastid (18)
- origin INTEGER {
- unknown (0) ,
- natural (1) , -- normal biological entity
- natmut (2) , -- naturally occurring mutant
- mut (3) , -- artificially mutagenized
- artificial (4) , -- artificially engineered
- synthetic (5) , -- purely synthetic
- other (255) } DEFAULT unknown ,
- org Org-ref ,
- subtype SEQUENCE OF SubSource OPTIONAL ,
- is-focus NULL OPTIONAL } -- to distinguish biological focus
- SubSource ::= SEQUENCE {
- subtype INTEGER {
- chromosome (1) ,
- map (2) ,
- clone (3) ,
- subclone (4) ,
- haplotype (5) ,
- genotype (6) ,
- sex (7) ,
- cell-line (8) ,
- cell-type (9) ,
- tissue-type (10) ,
- clone-lib (11) ,
- dev-stage (12) ,
- frequency (13) ,
- germline (14) ,
- rearranged (15) ,
- lab-host (16) ,
- pop-variant (17) ,
- tissue-lib (18) ,
- plasmid-name (19) ,
- transposon-name (20) ,
- insertion-seq-name (21) ,
- plastid-name (22) ,
- country (23) ,
- segment (24) ,
- endogenous-virus-name (25) ,
- transgenic (26) ,
- environmental-sample (27) ,
- isolation-source (28) ,
- other (255) } ,
- name VisibleString ,
- attrib VisibleString OPTIONAL } -- attribution/source of this name
-
- END
- --**********************************************************************
- --
- -- NCBI Protein
- -- by James Ostell, 1990
- -- version 0.8
- --
- --**********************************************************************
- NCBI-Protein DEFINITIONS ::=
- BEGIN
- EXPORTS Prot-ref;
- IMPORTS Dbtag FROM NCBI-General;
- --*** Prot-ref ***********************************************
- --*
- --* Reference to a protein name
- --*
- Prot-ref ::= SEQUENCE {
- name SET OF VisibleString OPTIONAL , -- protein name
- desc VisibleString OPTIONAL , -- description (instead of name)
- ec SET OF VisibleString OPTIONAL , -- E.C. number(s)
- activity SET OF VisibleString OPTIONAL , -- activities
- db SET OF Dbtag OPTIONAL , -- ids in other dbases
- processed ENUMERATED { -- processing status
- not-set (0) ,
- preprotein (1) ,
- mature (2) ,
- signal-peptide (3) ,
- transit-peptide (4) } DEFAULT not-set }
- END
- --********************************************************************
- --
- -- Transcription Initiation Site Feature Data Block
- -- James Ostell, 1991
- -- Philip Bucher, David Ghosh
- -- version 1.1
- --
- --
- --
- --********************************************************************
- NCBI-TxInit DEFINITIONS ::=
- BEGIN
- EXPORTS Txinit;
- IMPORTS Gene-ref FROM NCBI-Gene
- Prot-ref FROM NCBI-Protein
- Org-ref FROM NCBI-Organism;
- Txinit ::= SEQUENCE {
- name VisibleString , -- descriptive name of initiation site
- syn SEQUENCE OF VisibleString OPTIONAL , -- synonyms
- gene SEQUENCE OF Gene-ref OPTIONAL , -- gene(s) transcribed
- protein SEQUENCE OF Prot-ref OPTIONAL , -- protein(s) produced
- rna SEQUENCE OF VisibleString OPTIONAL , -- rna(s) produced
- expression VisibleString OPTIONAL , -- tissue/time of expression
- txsystem ENUMERATED { -- transcription apparatus used at this site
- unknown (0) ,
- pol1 (1) , -- eukaryotic Pol I
- pol2 (2) , -- eukaryotic Pol II
- pol3 (3) , -- eukaryotic Pol III
- bacterial (4) ,
- viral (5) ,
- rna (6) , -- RNA replicase
- organelle (7) ,
- other (255) } ,
- txdescr VisibleString OPTIONAL , -- modifiers on txsystem
- txorg Org-ref OPTIONAL , -- organism supplying transcription apparatus
- mapping-precise BOOLEAN DEFAULT FALSE , -- mapping precise or approx
- location-accurate BOOLEAN DEFAULT FALSE , -- does Seq-loc reflect mapping
- inittype ENUMERATED {
- unknown (0) ,
- single (1) ,
- multiple (2) ,
- region (3) } OPTIONAL ,
- evidence SET OF Tx-evidence OPTIONAL }
- Tx-evidence ::= SEQUENCE {
- exp-code ENUMERATED {
- unknown (0) ,
- rna-seq (1) , -- direct RNA sequencing
- rna-size (2) , -- RNA length measurement
- np-map (3) , -- nuclease protection mapping with homologous sequence ladder
- np-size (4) , -- nuclease protected fragment length measurement
- pe-seq (5) , -- dideoxy RNA sequencing
- cDNA-seq (6) , -- full-length cDNA sequencing
- pe-map (7) , -- primer extension mapping with homologous sequence ladder
- pe-size (8) , -- primer extension product length measurement
- pseudo-seq (9) , -- full-length processed pseudogene sequencing
- rev-pe-map (10) , -- see NOTE (1) below
- other (255) } ,
- expression-system ENUMERATED {
- unknown (0) ,
- physiological (1) ,
- in-vitro (2) ,
- oocyte (3) ,
- transfection (4) ,
- transgenic (5) ,
- other (255) } DEFAULT physiological ,
- low-prec-data BOOLEAN DEFAULT FALSE ,
- from-homolog BOOLEAN DEFAULT FALSE } -- experiment actually done on
- -- close homolog
- -- NOTE (1) length measurement of a reverse direction primer-extension
- -- product (blocked by RNA 5'end) by comparison with
- -- homologous sequence ladder (J. Mol. Biol. 199, 587)
-
- END