signal_seq.hpp
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- /*
- * ===========================================================================
- * PRODUCTION $Log: signal_seq.hpp,v $
- * PRODUCTION Revision 1000.1 2004/04/12 17:48:09 gouriano
- * PRODUCTION PRODUCTION: UPGRADED [CATCHUP_003] Dev-tree R1.2
- * PRODUCTION
- * ===========================================================================
- */
- /* $Id: signal_seq.hpp,v 1000.1 2004/04/12 17:48:09 gouriano Exp $
- * ===========================================================================
- *
- * PUBLIC DOMAIN NOTICE
- * National Center for Biotechnology Information
- *
- * This software/database is a "United States Government Work" under the
- * terms of the United States Copyright Act. It was written as part of
- * the author's official duties as a United States Government employee and
- * thus cannot be copyrighted. This software/database is freely available
- * to the public for use. The National Library of Medicine and the U.S.
- * Government have not placed any restriction on its use or reproduction.
- *
- * Although all reasonable efforts have been taken to ensure the accuracy
- * and reliability of the software and data, the NLM and the U.S.
- * Government do not and cannot warrant the performance or results that
- * may be obtained by using this software or data. The NLM and the U.S.
- * Government disclaim all warranties, express or implied, including
- * warranties of performance, merchantability or fitness for any particular
- * purpose.
- *
- * Please cite the author in any work or product based on this material.
- *
- * ===========================================================================
- *
- * Authors: Josh Cherry
- *
- * File Description: Prediction of signal sequences from protein sequence
- * according to von Heijne, 1986 and 1987
- *
- */
- #ifndef ALGO_SEQUENCE___SIGNAL_SEQ__HPP
- #define ALGO_SEQUENCE___SIGNAL_SEQ__HPP
- #include <corelib/ncbistd.hpp>
- #include <objects/seqloc/Seq_loc.hpp>
- #include <objmgr/seq_vector.hpp>
- #include <vector>
- BEGIN_NCBI_SCOPE
- /// Protein signal sequence prediction according to
- /// von Heijne, 1986 (PMID 3714490, as modified in his book).
- class NCBI_XALGOSEQ_EXPORT CSignalSeq
- {
- public:
- enum EDomain {
- eEukaryotic,
- eBacterial
- };
- /// Find the most likely predicted signal sequence cleavage site (pos)
- /// and the associated score (>3.5 suggests a real signal sequence).
- /// Constrain pos to be no larger than max_pos. Positions
- /// refer to residue just before cleaved bond.
- /// Length of seq must be at least 15, and max_pos must be
- /// at least 12.
- /// For std char containers, seq must be in ncbistdaa.
- static void Predict(const string& seq, EDomain domain,
- TSeqPos max_pos, TSeqPos& pos, double& score);
- static void Predict(const vector<char>& seq, EDomain domain,
- TSeqPos max_pos, TSeqPos& pos, double& score);
- static void Predict(const objects::CSeqVector& seq, EDomain domain,
- TSeqPos max_pos, TSeqPos& pos, double& score);
- private:
- template<class Seq> friend
- void x_PredictSignalSeq(const Seq& seq, CSignalSeq::EDomain domain,
- TSeqPos max_pos, TSeqPos& pos, double& score);
- };
- END_NCBI_SCOPE
- #endif // ALGO_SEQUENCE___SIGNAL_SEQ__HPP
- /*
- * ===========================================================================
- * $Log: signal_seq.hpp,v $
- * Revision 1000.1 2004/04/12 17:48:09 gouriano
- * PRODUCTION: UPGRADED [CATCHUP_003] Dev-tree R1.2
- *
- * Revision 1.2 2004/03/11 17:12:07 dicuccio
- * Removed member static const arrays in favor of private static arrays
- *
- * Revision 1.1 2003/09/10 15:31:34 jcherry
- * Initial version
- *
- * ===========================================================================
- */