Optical investigations reveal the effects of 2-aminoethyldiphenyl borate on STIM1 puncta formation - 源码 - 源码 - 免费下载

Optical investigations reveal the effects of 2-aminoethyldiphenyl borate on STIM1 puncta formation

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资源说明：2-Aminoethyldiphenyl borate (2-APB) is the most commonly used pharmacological agent in the study of calcium release-activated channels (CRACs); however, its inhibitory mechanism to CRACs remains unclear. To address this issue, we systematically employed confocal imaging, dual-wavelength excitation photometry and FRET to examine the effects of 2-APB on the dynamic activities and function of STIM1 and Orai1, two key components of CRACs. Imaging results support that there are two signaling pathways

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