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资源说明：[ADDIS 1.x] Aggregate Data Drug Information System
ADDIS - Aggregate Data Drug Information System
==============================================
[](https://travis-ci.org/drugis/addis)
[ADDIS][1] is a software developed within the Dutch [Escher-project][2]
for managing and analyzing clinical trial information.
ADDIS comes with two built-in examples:
* An anti-depressants example modeled on the paper: [Hansen et
al., Annals of internal medicine, 143(6): 415-426, 2005][3]. All data
was extracted by us from the original papers.
* A hypertension example based on the EMA EPAR evaluating Edarbi. The
data were imported from ClinicalTrials.gov, with manual corrections
where needed.
Requirements
------------
ADDIS is made in [Java][4], and requires Java 7 (JRE 1.7) or newer. Most
modern operating systems ship with a suitable JRE.
Versions
--------
1.16.8: Bugfixes for export to ADDIS 2.
1.16.7: Add export to ADDIS 2. Require Java 7.
1.16.6: Bugfix release.
1.16.5: Bugfix release.
1.16.4: JSON export of benefit-risk models; bugfixes.
1.16.3: Bugfix release.
1.16.2: Bugfix release.
1.16.1: Updated to GeMTC 0.14.1 for bugfixes and minor improvements.
1.16: Drug treatments can now be stratified by dose and dosing type with
the new 'treatment' functionality. Dose stratifications can be used
in network meta-analyses and pairwise meta-analyses. Added
hypertension example data set. Allow importing of results from
clinicaltrials.gov (experimental). Fixed bugs which could lead to
data loss.
1.14.1: Bugfix release.
1.14: Network meta-analysis results can now be saved in the ADDIS data
file. In addition, the computations can be reset and there is a new
visual progress indicator.
1.12.5: Bugfix release.
1.12.4: The network meta-analysis simulation can be continued if it has
not converged yet, and there is a new GUI for checking convergence.
The benefit-risk analysis now uses the full covariance information
from network meta-analysis. Reduced download from 30MB to 15MB.
Bugfixes.
1.12.3: Bugfix release.
1.12.2: Bugfix release.
1.12.1: Input name of analyses in the first step of the wizard, not in
a pop-up dialog at the very end.
1.12: Add [BRAT table][10] and its value tree to benefit-risk view,
allow selection of baseline in benefit-risk analysis, enable BRAT
description of benefit-risk analysis, improve performance of network
meta-analysis wizard, clarify error dialog with bug reporting
instructions, fix many bugs.
1.10.1: Bugfix release
1.10: Enable combination treatment. Add "free text" ('Other') activity.
Allow multiple moments of measurement for each outcome. Add installer
and double-click loading of .addis data files on Windows.
1.8: Input study design (time structure), allow missing measurements,
generate summary of efficacy table according to EMA D80 template,
support of primary/secondary endpoints.
1.6.2: Bugfix release
1.6.1: Performance improvements for network meta-analysis, rank
probability table.
1.6: User interface improvements, risk-based sampling in MetaBR, new
schema-based XML format, added note taking in study wizard.
1.4: Lynd & O'Brien benefit-risk analysis, corrected meta-analysis,
network meta-analysis enhancements (assessment of convergence,
variance parameters, node-splitting analysis, R-dump of results,
memory management), tabbed views.
1.2.1: Bugfix release
1.2: Benefit-risk models based on a single study.
1.0: Welcome screen, limited editing, links to various information
systems (PubMed, medicines.org.uk, whocc.no) and many minor
improvements.
0.10: Benefit-risk analysis, baseline effect (heuristic) estimation
0.8.1: Faster network meta-analysis (updated library), minor fixes
0.8: Network meta-analysis, XML import/export
0.6: Added add-study-wizard, import from ClinicalTrials.gov
0.4.1: Fixed example data (studies Org 022 and 023), changed domain
to be version-specific.
0.4: Added meta-analysis, removed combined studies and MCDA-hookup.
Lots of minor changes.
0.2: Initial release.
Building ADDIS from source
--------------------------
All releases as well as a nightly build (see [the DrugIS website][5])
are distributed in a compiled format. However, we also provide source
for external development / verification. The sources can be checked out
of the [ADDIS Git repository][6].
In order to compile ADDIS, you need:
- Java >= 1.6
- [Maven 2][7]
- Other dependencies should be downloaded automatically by Maven2
Building is automatic with "mvn package".
Developing ADDIS using Eclipse
------------------------------
First, let Maven configure your workspace for use with Maven:
$ mvn eclipse:configure-workspace -Declipse.workspace=WORKSPACE_DIR
Use Maven to generate the eclipse project:
$ cd SOURCE_DIR
$ mvn eclipse:eclipse
Then import the project into Eclipse (File -> Import -> Existing projects).
License
-------
ADDIS is open source, and licensed under [GPLv3][8]. See
[LICENSE.txt][9] for more information.
Contact
-------
For contact information, see [the ADDIS website][1].
ADDIS Development Team
[1]: http://www.drugis.org/addis
[2]: http://www.tipharma.com/projects/efficiency-analysis-drug-discovery-process/the-escher-project.html
[3]: http://pubmed.com/16172440
[4]: http://www.java.com/getjava/
[5]: http://www.drugis.org/
[6]: https://github.com/gertvv/addis
[7]: http://maven.apache.org/download.html
[8]: http://gplv3.fsf.org/
[9]: https://github.com/gertvv/addis/blob/master/LICENSE.txt
[10]: http://dx.doi.org/10.1038/clpt.2010.291
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